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Yes, B12 shots for hangovers can be effective

This pilot study suggest that the nasal drops may be used as an alternative to injections because two thirds of ME/CFS patients reported a positive effect, accompanied by an increased number of steps, improvement of the RAND-36 physical functioning scale and the CIS20r fatigue scale, and a significant increase in serum vitamin B12 levels

Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance
