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Despite being dispensable for energy production, mitochondria in neutrophils remain functionally intact, suggesting that neutrophils might opt for the mitochondrial glutaminolysis pathway as an alternative means of supplementing NADPH during ROS generation (Furukawa et al., 2000) (Table 3)

Notwithstanding the age related relevance of the cellular defense mechanisms, the pleiotropic and redundant array of protective enzyme systems that counteract ROS include many that utilize GSH directly

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Schempp CM, Mller KA, Winghofer B, Schpf E, Simon JC

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