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In more severe cases, oral steroid bursts of 5-15 days (occasionally longer if necessary, but then it can be difficult and slow to wean the person off these medications

Most of the proteins are targeted for proteasomal degradation after being covalently modified with ubiquitin, a small protein with 76 amino acids, which is conjugated through the formation of an isopeptide bond between the -amino group of a lysine residue of the substrate and the COOH-terminal carboxylate (343)

10.1016/S0140-6736(14)61010-2 Lancet 111 Segura-AguilarJ.ParisI.MuozP.FerrariE.ZeccaL.ZuccaF

1), demonstrating the release of RSSH.Dialkyltrisulfide6 formation, however, also is observed as a major product (Scheme3, eq