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Finally, the diverse immune profiles and tumor heterogeneity across patients may influence the efficacy of anti-PD treatment, highlighting the need for the development of personalized approaches and biomarkers to overcome anti-PD resistance and guide more precise combinational therapeutic decisions to adjuvant PD-1/PD-L1 blockade therapy

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Shanmugam K, Ravindran S, Kurian GA, Rajesh M (2018) Fisetin confers cardioprotection against myocardial ischemia reperfusion injury by suppressing mitochondrial oxidative stress and mitochondrial dysfunction and inhibiting glycogen synthase kinase 3 activity

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