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Together, these interconnected mechanisms create a vicious cycle of neurodegeneration, ultimately leading to the clinical manifestations of AD
A crucial piece of evidence comes from the study of the deprotonated molecules of heavy metal-biothiol conjugates ( i.e
2018 doi: 10.1016/j.exger.2018.07.007
Beyond ECM degradation, MMPs also play critical roles in regulating inflammation and cellular behaviour by modulating growth factors, cytokines, chemokines, and cell surface receptors, thereby orchestrating a complex network of signaling events that ultimately drive IPF progression (Karsdal et al., 2016)
