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Amphetamine increases the concentration of dopamine in the synaptic cleft by entering the presynaptic neuron by diffusing across the neuronal membrane directly or through DAT, competitive reuptake inhibition at the transporter, and finally, the reversal of dopamine transport through DAT (i.e., dopamine efflux) [159,160,161]

Treatment with brensocatib prolonged the time until patients experienced their first exacerbation and increased the proportion who remained exacerbation-free throughout the year-long study

October 21, 2025

We typically recommend a weekly B12 injection at first for optimal results, but your provider can offer you personalized guidance according to your needs and lifestyle