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These changes occurred through direct effects on adipocyte biology rather than appetite suppression, as research models maintained normal feeding behavior while exhibiting significant reductions in individual adipocyte size

However, clinicians often report associated conditions like autoimmune thyroid disease (E06.3) or type 1 diabetes (E10) as secondary diagnoses when they coexist
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[DOI] [PubMed] [Google Scholar] 68.Huang Y, Cohen JC, Hobbs HH