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[206] demonstrated that crotalphin administered orally, intravenously, or via intraplantar injection in rats produced a long-lasting (5-day) antinociceptive effect by activating peripheral KOR opioid receptors in models of mechanical hyperalgesia induced by prostaglandin E2 and carrageenan

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This type of inflammation, called acute inflammation, works as a protective defense for the body, and then swiftly disappears when its job is done

These peptides are too short to cross-link IgE molecules on mast cell surfaces, so they cannot trigger mast cell degranulation