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However, LPCAT3 is not required for ferroptosis induction.31 Both, non-enzymatic (Fenton chemistry) and enzymatic (lipoxygenases, LOXs) mechanisms may trigger lipid peroxidation.33,34 However, the specific contribution of each mechanism is unclear and it may differ for different ferroptosis inducers.34 At which regulatory point iron contributes to ferroptosis is unclear

Furthermore, SLC7A11 overexpression or treatment with ferroptosis inhibitors has been shown to partly overcome the tumor growth suppression caused by BAP1 restoration in tumors (36, 76, 77)