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Description
This oxidative stress is characterized by elevated levels of superoxide radicals (O 2 ), hydrogen peroxide (H 2 O 2 ), hydroxyl radicals (OH), nitric oxide (NO), nitric oxide synthase (NOS), NADPH oxidase 2, peroxynitrite (ONOO), malondialdehyde (MDA), and 4-hydroxynonenal (4-HNE)

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Ion channel activity modulation by the SARS-CoV-1-ORF3a protein also modulates viral release [39]

What it targets Disrupts the FOXO4-p53 interaction so p53 can trigger apoptosis in senescent cells