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Hepatology 47: 511520 Lin CP, Liu CR, Lee CN, Chan TS, Liu HE (2010) Targeting cMyc as a novel approach for hepatocellular carcinoma

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After the initiation of folic acid fortification, mean plasma folate concentrations increased from 4.6 to 10 ng/mL, homocysteine concentrations fell from 10.1 to 9.4 mol/L, and the prevalence of homocysteine levels above 13 mol/L dropped from about 19% to about 10%

The human gastrointestinal tract contains significant amounts of the enzyme GGT, which recycles GSH precursors and may prevent significant intact absorption of GSH per se from oral supplementation