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The decreased expression of ATGL inhibits fatty acid mobilization of intracellular lipid droplets and promotes lipid droplet's aggregation, leading to renal tubular epithelial cell injury and renal fibrosis, and ultimately promotes the transformation of AKI to CKD[27]

The peptide decreased the fluorescence intensity of H2AX signals, a marker of DNA damage, and appeared to have lowered apoptosis rates as indicated by Annexin-V staining

And just like a medication that never reaches the bloodstream cannot produce results, a peptide that degrades in stomach acid before absorption cannot deliver on its potential