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We and others also demonstrated that hemin induces the expression of NRF2 in SCD erythroblasts and animal models and such effect is mitigated by administration of dimethyl fumarate (DMF) 23,24 , an FDA-approved drug for the treatment of multiple sclerosis

Such combination therapy has been suggested to be feasible and MRI scans demonstrated presence of BBB disruptions up to 2 cm in the targeted regions

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DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation