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Superoxide anion (O 2 ) and hydrogen peroxide (H 2 O 2 ) are produced in mitochondria, endoplasmic reticulum (ER), peroxisomes, and the cytosol by enzymes including respiratory complexes (Turrens 2003), NADPH oxidases (NOX) (Bedard and Krause 2007), uncoupled nitric oxide synthase (Montezano and Touyz 2012), monoamine oxidase (Pizzinat et al

This may lead to new vascular targeting strategies aimed at tailoring vessel function to optimize drug response

However, oxidative stress and associated decreases in levels of glutathione (GSH) are known to play a central role in ALD