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These effects include loss of bone density, endothelial and immune dysfunction, sarcopenia, and systemic cellular stress induced by environmental factors such as microgravity, atmospheric conditions, radiation exposure and mental and physical stress

doi: 10.1038/s41467-023-36209-5, [DOI] [PMC free article] [PubMed] [Google Scholar] Yellen G

Every oral remedy runs into the same wall: the GI tract
