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10.1016/j.brainresbull.2017.01.024 Brain Res

By preserving NAD+ and SAM in both fat and muscle tissue, NNMT inhibition may theoretically address the metabolic dysfunction underlying both excessive fat storage and impaired muscle maintenance
molecular drivers governing neuronal Nogo receptor-dependent myelin plasticity and integrity

this is a promising result, but is not definitive because 6 months may be too short to detect a change in the absence of treatment