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The lower RMSF values for residues 200 to 400 in the Arbutin_d mode are hypothesized to be due to the hydroxyphenyl group of Arbutin_d facing the L3 region, where R289 tends to interact with the hydroxyphenyl group of Arbutin, stabilizing this region

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In cosmetic protocols it is applied twice daily as a serum or cream for a minimum of 8 weeks for measurable effect

For in vitro-in vivo correlation, Clj m per kg body weight was calculated using the following measurements for Sprague-Dawley rats: 44.8 mg of protein per g of liver, 40 g of liver per kg of body weight