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The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production

Besides, a study employing the nuclear magnetic resonance spectroscopy illustrated that E2 appeared to induce glycolysis, whereas tamoxifen reduced it (208210)

doi:10.1038/nm0901-1010 Tanaka K, Sasayama T, Irino Y et al (2015) Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment

This strategy is the basis for many anticancer therapeutics, including chemotherapeutics, radiotherapies, and most small-molecule inhibitor-based therapies, which impair tumor metabolism and induce excessive ROS accumulation, inducing cell toxicity and death