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doi: 10.1038/aps.2009.24
A 2012 review of all known studies determined that daily B12 losses in apparently healthy adults and elderly range from 1.4 to 5.1 g (Doets, 2012)

doi: 10.1002/JSFA.8053 19 SaleemSJafriLHaqIUChangLCCalderwoodDGreenBDet al

GHK-Cu Side Effects & Safety GHK-Cu has a long topical safety record and a shorter, mostly anecdotal injectable record
