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Description
Roles of IGF-1, IGF-1R, and IGFBPs in vascular smooth and endothelial cells IGF-1 and IGF-1R are expressed by vascular smooth muscle cells (VSMCs), endothelial cells (ECs), and macrophages (34), and together with different IGFBPs, they are considered significant regulators of atherosclerosis pathophysiology whose expression is downregulated in atherosclerotic lesions (4850)

doi: 10.1080/15548627.2025.2481126 53 BhattiJSBhattiGKReddyPH

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Safety Profile & Considerations Current understanding suggests: Generally well-tolerated in research settings No significant toxicity signals in preclinical studies Does not appear to suppress immune function However: Not approved for veterinary use Limited large-scale clinical trials in animals Should only be considered under qualified veterinary supervision What Veterinarians Are Observing In integrative and regenerative veterinary settings, BPC-157 is being explored as part of broader healing protocols
