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Description
Biologics [e.g., TNF- inhibitors (etanercept), IL-6R blockers (tocilizumab)]: Effective in 60 - 70% of patients but incur prohibitive costs ($20,000 - 50,000 annually), limiting accessibility (only 10 - 20% treated in low-resource settings) (5, 6)
the predominant sub-cellular distribution is in the cytosol and mitochondria
The bulky ring may cause excessive flexibility or steric hindrance, resulting in poor binding
WHAT ARE THE SIGNS OF B12 DEFICIENCY
