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CCK8 assay For cytotoxicity assay, the cells grown in the logarithmic phase were seeded into 96-well plates (7 10 3 cells/well) for 24 h, then exposed to different concentrations (10, 5, 1, 0.1, 0.01 and 0.001 M) of the test compounds for 72 h

Therefore, the administration of synthetic PPAR- agonists, so called thiazolidinediones, which are widely used to improve insulin resistance in type 2 diabetes (Quinn et al., 2008), has also shown therapeutic efficacy in PCOS management

Micromanaging vascular smooth muscle cell differentiation and phenotypic modulation

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