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Hepatic manifestations span a broad spectrum, ranging from isolated mild elevations in transaminases to advanced cirrhosis with portal hypertension or acute liver failure

Methodologically rigorous studies that couple pathway inhibition to predefined immune and clinical endpoints, deploy standardized biospecimen workflows and use harmonized safety reporting are required to determine whether neurotrophin-targeted strategies can remodel the osteosarcoma microenvironment toward durable immune control

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The molecular docking results revealed that the VPA and CBZ compounds could interact with the identified targets active sites, and thus, the identified proteins may be suited for oxidative stress mediated therapy in epilepsy