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Extracellular Matrix (ECM) Remodeling Increases synthesis of: Collagen Elastin Glycosaminoglycans Proteoglycans Regulates metalloproteinases for balanced tissue remodeling

in terms of quantity, there is a threshold effect: a study of Indian middle school students (28) indicated that when daily protein intake was 1.2 g/kg body weight, intestinal tryptophan supply was stable, 5-HT (5-hydroxytryptamine) synthesis was sufficient, and depression scores decreased significantly (mean difference = 1.8 points, P 1 g/day) has a small effect on moderate depression, while low-dose supplements ( 0.5 g/day) provide no benefitthis dose-response relationship was not discussed in the original analysis (65, 66)

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