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Age-associated cognitive decline (ACD) is largely subclinical and is often experienced as declines in memory, problem-solving, processing speed and conceptual reasoning [5,6], and is associated with structural changes in the brain [7]

It has been shown that gastrodin relieved vincristine-induced CIPN in rats by inhibiting the activation of spinal microglia through CX3CL1 and its receptor, CX3CR1 [136]

The values obtained in the experiment were statistically evaluated using the Wilcoxon rank sum test, and differences were considered significant when the significance level p was less than 0.05