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We recommend patients apply the preparation directly to affected joints three times daily
Preclinical studies indicate that metformin promotes M2 macrophage polarization through STAT6 activation, which facilitates tissue repair and attenuates TGF-1-mediated renal fibrosis (109)
This state of microglial activation resulted in elevated levels of the anti-inflammatory cytokine IL-4 and decreased levels of the pro-inflammatory cytokines, including IL-1 and TNF- [215]
One such concern is the release of a thiol intermediate
