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In the cells of extant organisms, the vast majority of the proteins in the mitochondria (numbering approximately 1500 different types in mammals) are coded by nuclear DNA, but the genes for some, if not most, of them are thought to be of bacterial origin, having been transferred to the eukaryotic nucleus during evolution

An 181 bp duplication event was identified in the CYP9f2 candidate gene in one Indian colony sample (SRR1529388, see above) but was annotated as a non-coding transcript

The systemic administration of KA triggers seizure activity, which leads to a large production of ROS, causing ROS-induced DNA damage, protein oxidation, and lipid peroxidation, and subsequent seizure-induced hippocampal cell death 32,33

Consequently, free radicals accumulate substantially in the substantia nigra, and cytotoxic substances that cannot be cleared aggregate within neurons, ultimately leading to cell death and DA neurons [57]