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It suggests that local AT health, particularly in GWAT, is sufficient to cause IR or MASLD in obesity

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306 Though numbers of clinical trials have suggested that mipomersen has efficacy in lowering ApoB-related lipoproteins in patients with different hypercholesterolemic phenotype, its approval is currently only available to treat homozygous familial hypercholesterolemia as an adjunctive orphan drug due to adverse effects such as flu-like symptoms and transaminitis

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& Xing, W

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doi: 10.1016/j.lfs.2016.02.002

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