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Mitochondria-targeted drug delivery system for cancer treatment

The consequences of impaired methylation pathways are devastating and result in reduced activity of proteins, reduced production of brain neurotransmitters (seretonin, dopamine, GABA etc), increased inflammation, decreased production of glutathione, alterations in DNA and in cell membrane signaling

More researches are needed to further explore the specific mechanisms underlying this relationship in order to offer new strategies for treating depression
Despite these differences, both studies support the notion that opioids inhibit GABA release from interneurons in the PAG, which disinhibit (i.e., excite) glutamate projections to off-cells
