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Therefore, further studies to elucidate the pharmacological mechanisms of lanosterol and 25-hydroxycholesterol are necessary to promote utilization in the clinical treatment of cataracts

Email: [email protected] Received: 07 Feburary 2023 / Revised: 02 March 2023 / Accepted: 22 March 2023 / Published: 29 March 2023 DOI: 10.31491/APT.2023.03.109 Abstract Sleep deprivation is known to cause memory impairment and is associated with inflammation and cell damage linked to neurodegenerative diseases

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Therefore, while aware that the pharmacological modulation of the NRF2/ARE pathway could undeniably offer new therapeutic opportunities for diseases related to OS, we should at the same time consider that most of the currently known activators of NRF2 are not particularly specific, leading to an increased risk of off target toxic effects