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doi: 10.3389/fphar.2025.1516603 Received 24 October 2024 Accepted 10 March 2025 Published 25 April 2025 Volume 16 - 2025 Edited by Wei Peng, Chengdu University of Traditional Chinese Medicine, China Reviewed by James Hardwick, Northeast Ohio Medical University, United States Dandan Tang, Sichuan College of Traditional Chinese Medicine, China Updates Copyright 2025 Zhu, Jia and Zhang

In addition, the treatment of nicotinamide (NAM), a form of vitamin B3, suppressed the activity of sirtuin-1 (SIRT1), a regulator of cellular stress resistance, and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1), a key transcriptional coactivator involved in mitochondrial biogenesis and energy metabolism

[DOI] [PubMed] [Google Scholar] 59.Ciofu O., Smith S., Lykkesfeldt J

This activity is initiated by the ten-eleven translocation (TET) enzyme family that includes TET1, TET2 and TET3