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A reader is best served by holding two things at once: the mechanism is genuinely interesting, and the human evidence does not yet exist
Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
Stacking 5-Amino-1MQ for Enhanced Results (links corrected) Fat Loss Synergy AOD-9604 Targets lipolysis without anabolic effects
Most run it once daily in the morning
