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Interestingly, in ferroptosis research, ibuprofen has been shown to downregulate the Nrf2 signaling pathway, thereby inducing ferroptosis in glioblastoma cells (Wang Y

doi: 10.1038/s41589-022-01249-3 5 DavinelliSMedoroAIntrieriMSasoLScapagniniGKangJX
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There is also some concern that long-term use of high-dose glutathione may deplete other nutrients such as zinc
