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The so-called myokines, produced by the myocytes and released by muscle contraction during physical exercise, have autocrine, paracrine, and endocrine functions, and help perform the regulation of the immunometabolism thanks to their ability to induce significant metabolic, energetic and hormonal changes (Pillon et al., 2013

The metabolic pathway of glutaminolysis becomes essential under hypoxic conditions as it provides necessary energy and maintains metabolic intermediates through glutamine metabolism

By age 60, that concentration drops to approximately 0.08 mg per liter

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