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10.1089/acm.2006.12.881 Summary Keywords vitamin B12, efficacy, bioavailability, therapeutic approaches, meta-analysis, cobalamin Citation Mazur M, Ndokaj A, Salerno C, Vallone J, Ardan R, Bietolini S, Carrouel F, Wilk A, Sarig R, Ottolenghi L and Bourgeois D (2025) Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis

Features that distinguish acneiform eruptions from acne vulgaris are: a positive time relationship between the introduction of the drug and the onset, a sudden and uncommon age of onset, pruritus, a monomorphic pattern and an involvement of seborrheic and extra-seborrheic areas such as the face, the neck, shoulders, arms, chest, and back [1,8]

Deficiencies can occur with medical conditions such as atrophic gastritis (which causes thinning of the stomach lining), pernicious anaemia, Crohns disease, celiac disease, lupus, or other immune system disorders and certain medications

Proliferating white blood cells produce increased amounts of haptocorrin (transcobalamin I) , a B12-binding protein