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Thrombosis (when blood clots block veins and arteries) may occur, especially if a patient has one of the following risk factors: advanced age, cardiovascular issues, estrogen use, arterial or venous thrombosis past history, hypercoagulable conditions, hyperviscosity, long periods of immobilization, and indwelling vascular catheters

Methods Enzymol 1981

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The gained information has allowed to explain some phenomena observed in toxicological studies performed at the level of cell cultures and of isolated tissue and organ preparations, and to finally propose an explanation for the peculiar toxicological behavior ( i.e