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In other model systems, maintained rates of fatty acid beta-oxidation with aging have been linked with longevity, while the lifespan extension in response to DR has been shown to occur through a similar mechanism as the lifespan extension that occurs by overexpression of fatty acid beta-oxidation pathway genes in Drosophila (Doering et al., 2023

The clinical evidence for these drugs is robust and their safety profiles are well-established

Acute toxicity Toxicity studies of DTN was performed, which defines the lethal dose versus the non-lethal dose of the test compound in the animal model

In a randomized, single-center, double-blind, placebo-controlled clinical trial, the oral administration of 600 mg/kg ALA twice daily for over 6 months resulted in significant symptomatic improvements in DPN patients