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Resveratrol alleviates vascular endothelial damage caused by lower-extremity ischemia reperfusion (I/R) through regulating keap1/nrf2 signaling-mediated oxidative stress
As a result, these mitochondria shift from being the energy factory of cells to becoming the primary pathological source of reactive oxygen species, such as superoxide anion ( Second, SUA-induced insulin resistance state activates systemic ROS generation pathways
But that's true only in terms of the up-front cost
