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Because assays of these enzymes are commonly available and frequently ordered to screen for hepatobiliary disease with elevated levels, it is important to realize that subnormal levels may also be indicative of many treatable diseases

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Research published in JCI Insight describes tirzepatide as an "imbalanced and biased" dual agonist, meaning it shows equal affinity for the GIP receptor compared to native GIP but approximately 5-fold weaker affinity for the GLP-1 receptor compared to native GLP-1

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