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Heat, moisture, oxygen exposure, light, and repeated warming can still reduce quality over time
The choice between them boils down to what the medications guidelines require and patient safety considerations: Use sterile (preservative-free) water when indicated for sensitive situations (newborns, intrathecal use, single-dose needs), and use bacteriostatic water when a multi-dose solution is needed and its safe to do so

(1987) Clinical usefulness of intrathecal injection of methylcobalamin in patients with diabetic neuropathy
Biochem Biophys Res Commun 331(4):12451252 Upadhyay N et al (2021) Recent anti-angiogenic drug discovery efforts to combat cancer
