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DHAR and GR activities convert the DHA translocated from the lumen and the DHA generated in the stroma to AsA (Asada, AsA-GSH pathway in mitochondria The presence and activity of AsA-GSH cycle enzymes in mitochondria of plant cells have been established, and this cycle plays an important role in protecting mitochondrion against the toxic ROS regularly produced in respiratory chain reactions (Leonardis et al., 2000

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( in vivo has revealed that vincristine-induced ROS overproduction may also increase the activity of the enzyme dipeptidylpeptidase IV and decrease the levels of spinal endomorphin-2