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326 More detailed research shows that at least one of two RT fragments, residues 1199 of terminal protein (TP) domain and 680842 of Rnase H (RH), is necessary for Hsp60 binding

Carr AS, Cardwell CR, McCarron PO, McConville J

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FOXO4-DRI acts as a competitive inhibitor of this interaction binding directly to the transactivation domain 2 (TAD2) of p53, displacing FOXO4, and allowing phosphorylated p53 to be exported from the nucleus and directed to mitochondria, where it activates BAX, triggers caspase-3 cleavage (via the p53/BCL-2/Caspase-3 signalling pathway), and drives cell-intrinsic apoptosis