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Oncogene-stimulated congestion at the KEAP1 stress signaling hub allows bypass of NRF2 and induction of NRF2-target genes that promote tumor survival

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Our in vitro studies on primary peritoneal macrophages from Gstp / mice and wild-type mice, and cell lines of RAW264.7 and THP-1 indicated that GSTP inhibited LPS-induced HMGB1 release through preventing its translocation from the nucleus to cytoplasm