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Animal experiments All animal procedures were performed in accordance with the ethical standards approved by the Animal Care and Ethics Committee of the Second Affiliated Hospital, Zhejiang University School of Medicine

Stacking peptides correctly means understanding the biology deeply enough to know which mechanisms enhance each other and which simply create redundant signalling at the same receptor

Considering the position of the Gly 1228, we could argue that the mutation G1228D will trigger a steric hindrance with T998 that is tightly constrained by F583 and cannot move easily in the apo and LTC 4 -bound conformations

PLoS Med 3: e102