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At the severe end of this spectrum, persistent energy deficiency may lead to functional hypothalamic amenorrhea (FHA), characterized by suppression of GnRH pulsatility and consequent disruption of ovulatory function, representing a reversible but clinically significant manifestation of energy-conserving neuroendocrine adaptation [90]
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The most important member of the SOCS family is SOCS3, which can block JAK/STAT3 signaling in response to mitosis, growth factors, and cytokines (Xiao et al
Proton irradiation significantly reduces crypt viability, mucosal surface area, and cellular proliferation
