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IOP Publishing Tur JA, Bibiloni MM (2016) Encyclopedia of food and health

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Reference OBrien, Jimenez, Hauser, Factor, Burke, Mandri and Castro-Gayol54 Ten participants (5 in each arm) discontinued the trial

The mechanism linking RDW to cardiovascular risk likely involves chronic inflammation (RDW reflects inflammatory burden, which drives atherosclerosis), oxidative stress (damages both red blood cells and arterial walls), poor nutritional status (deficiencies affecting red blood cells also affect cardiovascular health), and overall physiological stress and biological aging (high RDW indicates reduced reserve capacity)