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This approach generally offers stronger and more stable adhesion than electrostatic interactions, providing prolonged residence time, although it requires more complex chemistry and may be susceptible to cleavage in reducing environments

Nrf2 -null mice suffer from acute hepatotoxicity after acetaminophen exposure ( Nrf2 -null mice ( Nrf2 -null mice are more susceptible to cigarette smoke-induced emphysema (Rangasamy et al., 2004), bleomycin-induced pulmonary fibrosis ( Nrf2 gene has been linked to the reduced expression of Nrf2 and subsequent lung damage caused by hyperoxia ( NRF2 gene also harbors SNPs in the promoter region (Yamamoto et al., 2004), which have been linked to the risk of acute lung injury (Marzec et al., 2007)

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A PIC hydrogel, decorated with high concentrations of Matrigel isolated lamininentactin, or recombinantly produced laminin-111, successfully maintained human liver organoid cultures 10