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Vigorous shaking causes foaming and can lead to peptide aggregation or denaturation
It is a huge hurdle we and others in the B12 community are working on to overcome
doi: 10.1016/j.phymed.2025.156873 134 Del CuoreAPipitoneRMCasuccioAMazzolaMMPuleoMGPacinellaGet al
GHK-Cu is used both topically (in formulations) and by injection, depending on the goal
