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Alterations in the expression of transcription factors and the reduced folate carrier as a novel mechanism of antifolate resistance in human lLeukemia cells

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In particular, OS induces the production of oxidized DNA adducts, such as 8-hydroxy-2-deoxyguanosine (8OHdG) within the DNA, resulting in single- or double-strand breaks (140)

47 Two of four family members in Switzerland after a white-water rafting trip to Thailand acquired leptospirosis and developed a JHR after treatment with ceftriaxone, meropenem, and doxycycline with serious consequences of hypotension, requiring adrenergic therapy in one case, as well as impaired liver and renal function