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When the urothelium is damaged, Wnt can activate stem cell proliferation and differentiation at the basal layer, leading to rapid epithelial cell proliferation and subsequent tissue repair ( Figure 6 ) ( Figure 6 Furthermore, the Wnt signaling pathway can promote tissue fibrosis and the associated epithelial-mesenchymal transition (EMT) process

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S2), clearly demonstrating that uncatalyzed glutathionylation of regular protein thiols occurs much too slowly at low physiological GSSG concentrations to compete with glutaredoxin-dependent glutathionylation 63

Oral administration: 0.5-1 mg daily to compensate for lower bioavailability compared to injection